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5.8.6 – Presence and bothersome nature of symptoms

Measure (Authors, Year) Generic vs Specific, Purpose Administration, Number of Items, Number of Domains Measurement Properties

HIV Symptom Index18



Self-reported questionnaire

20 items

No domains

Validity: Good construct validity among people living with HIV on combination antiretroviral therapy.18

18Justice AC, Holmes W, Gifford AL, Rabeneck L, Zackin R, Sinclair G, Weissman S, Neidig J, Marcus C, Chesney M, Cohn SE, Wu AW; Adult AIDS Clinical Trials Unit Outcomes Committee. Development and validation of a self-completed HIV symptom index. J Clin Epidemiol. 2001 Dec;54 Suppl 1:S77-90. PubMed PMID: 11750213.